Functional Category:
Emulsifying agent; skin penetrant; tablet and capsule lubricant.
Applications in Pharmaceutical Formulation
Palmitic acid is used in oral and topical pharmaceutical formulations. Palmitic acid has been used in implants for sustained release of insulin in rats.(1,2
Description
Palmitic acid occurs as white crystalline scales with a slight characteristic odor and taste.
Stability and Storage Conditions
The bulk material should be stored in a well-closed container in a cool, dry, place.
Incompatibilities
Palmitic acid is incompatible with strong oxidizing agents and bases.
Safety
Palmitic acid is used in oral and topical pharmaceutical formulations and is generally regarded as nontoxic and nonirritant at the levels employed as an excipient. However, palmitic acid is reported to be an eye and skin irritant at high levels and is poisonous by intravenous administration. LD50 (mouse, IV): 57 mg/kg(3)