Tyrosine-Kinase Inhibitor

Tyrosine-kinase inhibitors (TKIs) are drugs that target the activity of enzymes known as tyrosine kinases, which are involved in the regulation of cell growth and proliferation. Tyrosine kinase is an enzyme that helps regulate a variety of cell processes, including cell growth, cell death, and migration. TKIs are used in the treatment of various types of cancer, such as chronic myeloid leukemia (CML), gastrointestinal stromal tumor (GIST), and renal cell carcinoma (RCC). TKIs work by blocking the activity of the tyrosine kinase, which prevents the cells from dividing and growing uncontrollably. In some cases, TKIs can also induce apoptosis, or programmed cell death, which helps to reduce the size of tumors. TKIs are often used in combination with other treatments, such as chemotherapy and radiation, to increase the effectiveness of the treatment.