Negative Inotropic

Negative inotropic activity is a type of medicinal activity that decreases the force of contraction of the heart muscle. This type of activity is usually associated with a specific type of pharmaceutical drug called a negative inotropic agent. These drugs work by blocking the calcium channels in the heart, which reduces the amount of calcium ions entering the muscle cells. This has the effect of decreasing the force of contraction of the heart muscle, leading to a decrease in the heart rate and a decrease in blood pressure. Negative inotropic agents are commonly used to treat heart failure, cardiac arrhythmias, and other conditions where it is necessary to reduce the force of contraction of the heart muscle.