Lithogenic

Lithogenic activity is the ability of a drug or substance to cause the formation of gallstones. Gallstones are hard deposits of cholesterol, calcium, and other substances that form in the gallbladder and can block the flow of bile, leading to abdominal pain and other symptoms. Lithogenic drugs and substances increase the concentration of cholesterol and other substances in the bile, leading to the formation of gallstones. The most common lithogenic drugs are oral contraceptives, some cholesterol-lowering medications, some antibiotics, and some anti-inflammatory agents. Other substances such as high-fat diets, high-calorie diets, and rapid weight loss can also increase the likelihood of gallstone formation.