Hepatotoxic

Hepatotoxicity is a form of toxic damage to the liver caused by the ingestion of drugs, chemicals, or other substances. It is one of the most common adverse effects of many drugs and can lead to serious health problems and even death. Symptoms of hepatotoxicity include nausea, abdominal pain, jaundice, dark urine, and fatigue. There are several mechanisms of action that can lead to hepatotoxicity. These include direct toxic effects, immune-mediated reactions, and metabolic changes. The most common mechanism of action is direct toxic effects, where a drug or chemical binds to a specific receptor on the liver cell, resulting in a disruption of normal liver function. Immune-mediated reactions are also possible, where the drug or chemical triggers an immune response that leads to liver damage. Metabolic changes can also cause hepatotoxicity, where the drug or chemical alters the metabolism of the liver leading to an accumulation of metabolites that can be toxic.