Alcohol-Dehydrogenase Inhibitor

Alcohol dehydrogenase (ADH) is an enzyme found in the liver that breaks down alcohol into acetaldehyde, which is then further broken down into acetic acid. Acetic acid is then broken down into harmless water and carbon dioxide. Alcohol dehydrogenase inhibitors (ADHI) are compounds that block the action of ADH, preventing the breakdown of alcohol into acetaldehyde and acetic acid. By inhibiting ADH, these compounds can reduce the effects of alcohol and reduce the risk of alcohol-related diseases and disorders. The most common ADHI is disulfiram, which is used to treat alcohol dependence. Other ADHI include metronidazole, cimetidine, and naltrexone. These compounds work by preventing ADH from breaking down alcohol, thus allowing the alcohol to remain in the bloodstream longer and increasing its effects. This can help reduce alcohol consumption, reduce the risk of alcohol-related diseases and disorders, and reduce the symptoms of alcohol withdrawal.