Mediterranean Fever

Mediterranean Fever (MF) is an inherited autoinflammatory disorder that affects people of Mediterranean descent. It is characterized by recurrent episodes of inflammation of the serous membranes and joints, along with an elevated white blood cell count. Symptoms of the disorder often include fever, abdominal pain, chest pain, joint pain, and muscular pain. Other symptoms may include nodules in the skin, kidney problems, and inflammation of the eye. The cause of Mediterranean Fever is unknown, but it is believed to be an inherited disorder. It is caused by a mutation in the MEFV gene, which codes for a protein called pyrin. This protein is important for the regulation of inflammation in the body. When the gene is mutated, it can cause the protein to malfunction, leading to an excess of inflammation. Mediterranean Fever is typically treated with anti-inflammatory medications. Additionally, lifestyle modifications, such as avoiding triggers such as stress and certain foods, can help reduce the frequency of flares. In some cases, surgery may be necessary to treat joint pain or other complications associated with the disorder. It is important to note that there is no cure for Mediterranean Fever; however, with proper treatment and lifestyle modifications, symptoms can be managed and flares can be minimized.