Functional Category
Diluent; dry powder inhaler carrier.
Applications in Pharmaceutical Formulation
Inhalation lactose is widely used as a carrier, diluent, and flow aid in dry powder inhalation formulations. Inhalation lactose of suitable particle size can also be used to prepare soft pellets of dry powder inhaler formulations.
Description
Lactose occurs as white to off-white crystalline particles or powder. It is odorless and slightly sweet-tasting.
Stability and Storage Conditions
Inhalation lactose should be stored in a well-closed container in a cool, dry place.
Incompatibilities
Lactose is a reducing sugar. Typical reactions include the Maillard reaction with either primary(1) or secondary amines.(2)
Safety
Lactose is widely used in pharmaceutical formulations as a diluent in oral capsule and tablet formulations, and has a history of being used in dry powder inhaler formulations.