Hydroxyprogesterone caproate is a medication that is used to prevent preterm birth in women who have had a previous preterm delivery. It is a synthetic form of the hormone progesterone and works by increasing the production of progesterone in the body. It is administered as an intramuscular injection once a week until the 37th week of pregnancy. Common side effects of this medication include headache, nausea, vomiting, and abdominal pain.
Hydroxyprogesterone Caproate, previously sold under brand names like Proluton and Makena, was a medication used to reduce the risk of preterm birth in specific situations [1].
Here's a breakdown of its key points:
- Purpose: It aimed to lower the risk of having a baby too early (preterm) again in women pregnant with one baby and a history of preterm birth [2].
- How it worked: The exact mechanism is unknown [2].
- Important Note: In April 2023, the US Food and Drug Administration (FDA) withdrew approval due to concerns about effectiveness [3]. This means it's no longer available in the US market.
Other things to know:
- It was administered through injection, typically once a week [2].
- It was not intended for pregnancies with multiples (twins, triplets) or to stop ongoing preterm labor [2].
Current Status:
- While it may still be prescribed in some regions outside the US, it's crucial to consult a doctor for guidance on the most up-to-date recommendations for preventing preterm birth.
Disclaimer: I cannot provide medical advice. If you have questions about Hydroxyprogesterone Caproate or any other medication, consult a healthcare professional.