Goserelin is a synthetic form of gonadotropin-releasing hormone (GnRH) that is used to treat certain types of cancers, such as breast and prostate cancer, as well as endometriosis. It works by blocking the production of hormones that stimulate the growth of cancer cells and endometriosis. Goserelin is administered through an injection, typically once a month, and can be used in combination with other treatments such as surgery, radiation and chemotherapy. Common side effects include hot flashes, pain at the injection site, headache and nausea.
Goserelin, sold under the brand name Zoladex among others, is a medication which is used to suppress production of the sex hormones (testosterone and estrogen), particularly in the treatment of breast and prostate cancer. It is a type of hormone therapy medication known as a gonadotropin-releasing hormone (GnRH) agonist.
Goserelin works by initially stimulating the pituitary gland to release more luteinizing hormone (LH). This LH surge causes a temporary increase in sex hormone levels (testosterone in men and estrogen in women) for a short period of time. However, continued use of goserelin reduces the pituitary gland's sensitivity to GnRH, which ultimately leads to decreased LH release and a reduction in sex hormone production.
Here are some of the conditions that goserelin is used to treat:
- Hormone-sensitive breast cancer in premenopausal women
- Prostate cancer
- Endometriosis
- Uterine fibroids
- Abnormal uterine bleeding
Goserelin is typically given as an injection under the skin (subcutaneously) or as an implant placed under the skin. The frequency of administration depends on the specific condition being treated and the formulation of goserelin used.
Common side effects of goserelin can include hot flashes, vaginal dryness, decreased sex drive, bone loss, and breast pain. These side effects are similar to those experienced by women going through menopause.
Goserelin is a prescription medication and should only be used under the supervision of a doctor. If you have any questions about goserelin, please talk to your doctor.