Glasdegib is a prescription medication used to treat adults with newly-diagnosed acute myeloid leukemia (AML). It is a type of cancer that affects the bone marrow and blood cells. Glasdegib is taken either in combination with chemotherapy or as a single-agent therapy. It works by blocking a protein called smoothened that helps cancer cells to survive and grow. Common side effects of Glasdegib include nausea, fatigue, diarrhea, infection, and low levels of red and white blood cells.
Glasdegib is a medication used to treat a specific type of leukemia. Here's a breakdown of its key features:
- Brand name: Daurismo [Wikipedia]
- Purpose: Treats newly diagnosed acute myeloid leukemia (AML) in adults who are either:
- 75 years or older [FDA approves glasdegib for AML in adults age 75 or older or who have comorbidities]
- Have other health conditions that prevent them from receiving intensive chemotherapy treatments [Glasdegib: Uses, Interactions, Mechanism of Action | DrugBank Online]
- Dosage: Taken orally (by mouth) at 100mg once daily, typically in combination with another medication called cytarabine [Wikipedia]
- How it works: Glasdegib belongs to a class of drugs called sonic hedgehog (SHh) pathway inhibitors. It targets a specific protein involved in this pathway that can be overactive in some cancers, including AML [Glasdegib - Wikipedia]
Important note: Glasdegib is not without side effects. Some common ones include anemia, fatigue, bleeding, and mouth sores [Wikipedia]. It's crucial to consult with a healthcare professional for a complete picture of the risks and benefits before taking Glasdegib.