Ethylestrenol (INN, BANM, USAN, JAN) is a synthetic, orally active anabolic-androgenic steroid (AAS) and derivative of nandrolone. It was originally developed in the late 1940s by Roussel-Uclaf and first made available as Estragynol in France in the early 1950s. It was subsequently marketed in the United States by Squibb under the brand name Maxibolin, and in the United Kingdom as Maxibolin Depot. Ethylestrenol is also known by its developmental code names RU-1776 and RU-1849. It is no longer marketed in any country and is a controlled substance in most countries.
Ethylestrenol, also known by brand names like Maxibolin and Orabolin, is an interesting case in the world of medicine. Here's what you need to know:
What it is:
- Ethylestrenol is an anabolic-androgenic steroid (AAS) medication [1].
- It falls under the category of 17α-alkylated steroids, a specific type of AAS with a modified structure for oral administration [2].
Past Medical Uses:
- Historically, Ethylestrenol was used for various purposes, including:
- Promoting weight gain and muscle growth [1, 3].
- Aiding in bone health by addressing osteoporosis and promoting bone growth in some cases [1, 3].
- Supporting recovery from chronic illnesses and injuries [3].
- Treating specific types of anemia [3].
Current Status:
- Due to potential health risks and the availability of safer alternatives, Ethylestrenol has been discontinued for use in humans in most countries [1].
- It's important to note that Ethylestrenol is still used in veterinary medicine in some regions like Australia and New Zealand [2].
Reasons for Discontinuation:
- Several factors contributed to Ethylestrenol's withdrawal from human medicine:
- Liver Damage: The 17α-alkylated structure can increase the risk of liver toxicity [2].
- Other Side Effects: Potential side effects include virilization (masculinization) in women and girls, stunted growth in children, and cardiovascular risks [2, 3].
- Safer Alternatives: The development of safer and more effective medications for the conditions Ethylestrenol was used for made it a less favorable option [1].
Important Takeaway:
Ethylestrenol is not a recommended medication for humans due to potential health risks. Safer alternatives are available for most conditions it was once prescribed for.