Brexanolone (generic name: allopregnanolone) is a hormone-based medicine that has been approved by the U.S. Food and Drug Administration (FDA) to treat severe postpartum depression (PPD) in women. It is a synthetic form of the naturally-occurring hormone allopregnanolone, which is produced in the body during pregnancy and believed to play a role in regulating mood. Brexanolone is administered as an intravenous (IV) infusion over a 60-hour period and works by increasing the amount of allopregnanolone in the body, restoring neurotransmitter balance, and providing fast and effective relief from the symptoms of PPD.
Brexanolone, sold under the brand name Zulresso, is a unique medication specifically approved for the treatment of postpartum depression (PPD) in adult women. Here's a closer look at its key points:
Approved Use:
- Brexanolone is the first and only FDA-approved medication specifically for treating postpartum depression.
- It is not intended for other types of depression or for use in men or children.
How it Works:
- Brexanolone belongs to a class of medications called allopregnanolone reuptake inhibitors.
- It works by increasing the levels of allopregnanolone in the brain. Allopregnanolone is a neurosteroid, a natural molecule in the brain that plays a role in mood regulation.
- By increasing allopregnanolone levels, brexanolone is thought to help improve mood and alleviate symptoms of postpartum depression.
Administration:
- Brexanolone is administered as a continuous intravenous (IV) infusion over 60 hours in a healthcare facility under the close supervision of a qualified healthcare professional.
- Due to the potential for excessive drowsiness or sudden loss of consciousness, it requires special monitoring and support throughout the treatment process.
Important Considerations:
- Brexanolone can cause various side effects, including sleepiness, dizziness, headache, nausea, and fatigue.
- It is not recommended for women who are pregnant or breastfeeding or have certain medical conditions, such as uncontrolled high blood pressure or a history of seizures.
- Due to the potential for serious side effects, brexanolone is only available through a restricted distribution program that requires healthcare providers to be specially certified to prescribe and administer the medication.