Zalcitabine (trade name: Hivid) is an anti-HIV drug used to treat HIV infection. It is a nucleoside analogue reverse transcriptase inhibitor (NRTI) that works by inhibiting the activity of reverse transcriptase, an enzyme that is used by the virus to copy its genetic material and replicate. Zalcitabine is used in combination with other anti-HIV drugs to treat HIV infection. It is usually taken twice daily, with meals. Common side effects of zalcitabine include nausea, vomiting, diarrhea, abdominal pain, anorexia, headache, and fever.
Zalcitabine, also known by the brand name Hivid, is a medication that was once used to treat HIV/AIDS. It is a nucleoside analog reverse-transcriptase inhibitor (NRTI), which means it works by stopping the human immunodeficiency virus (HIV) from reproducing in your body.
HIV uses an enzyme called reverse transcriptase to convert its genetic material (RNA) into DNA. DNA is then incorporated into the genetic material of the host cell, allowing the virus to replicate. Zalcitabine interferes with this process by blocking the action of reverse transcriptase.
Zalcitabine was first approved by the Food and Drug Administration (FDA) in 1992. However, it is no longer widely used because of the development of more effective and less toxic HIV medications. Zalcitabine is still available in some countries, but it is typically only used in people who cannot tolerate other HIV medications.
Zalcitabine is typically taken three times a day. The most common side effects of zalcitabine include mouth sores, diarrhea, and nerve pain. More serious side effects can include pancreatitis and a decrease in the number of white blood cells.
Zalcitabine is not a cure for HIV/AIDS, and it will not prevent you from transmitting HIV to others. If you are taking zalcitabine, it is important to see your doctor regularly to monitor your blood cell counts and for any side effects.