Vaborbactam is an antibiotic combination medicine used to treat certain complex urinary tract or serious bloodstream infections caused by certain bacteria. It is a combination of the antibiotic vabomere (meropenem) and the beta-lactamase inhibitor avibactam. Vaborbactam works by stopping the growth of bacteria. This antibiotic combination is usually given in combination with other antibiotics.
Vaborbactam is a medication that belongs to a class of drugs called beta-lactamase inhibitors. Here's a closer look at its key features:
Function: Vaborbactam itself doesn't directly kill bacteria. Instead, it works by protecting other antibiotics from being broken down by certain enzymes produced by bacteria. These enzymes, called beta-lactamases, can render some antibiotics ineffective.
Uses: Vaborbactam is primarily used in combination with another antibiotic, meropenem, under the brand name Vabomere. This combination therapy is specifically approved by the FDA to treat complicated urinary tract infections (cUTI), including kidney infections, caused by certain types of bacteria.
How it works: Vaborbactam binds to the beta-lactamase enzymes, preventing them from destroying meropenem. This allows meropenem to function effectively against bacteria that would otherwise be resistant due to beta-lactamase production.