International Numbering System (INS) for Food Additives 1505
Food additives Europe numbers: E1505
Functional Category
Plasticizer; solvent.
Applications in Pharmaceutical Formulation
Triethyl citrate and the related esters acetyltriethyl citrate, tributyl citrate, and acetyltributyl citrate are used to plasticize polymers in formulated pharmaceutical coatings.(1–5) The coating applications include capsules, tablets, beads, and granules for taste masking, immediate release, sustained-release, and enteric formulations. Triethyl citrate is also used as a direct food additive for flavoring, for solvency, and as a surface active agent
Description
Triethyl citrate is a clear, viscous, odorless, and practically colorless, hygroscopic liquid.
Stability and Storage Conditions
Triethyl citrate should be stored in a closed container in a cool, dry location. When stored in accordance with these conditions, triethyl citrate is a stable product.
Incompatibilities
Triethyl citrate is incompatible with strong alkalis and oxidizing materials.
Safety
Triethyl citrate is used in oral pharmaceutical formulations and as a direct food additive. It is generally regarded as a nontoxic and nonirritant material. However, ingestion of large quantities may be harmful. LD50 (mouse, IP): 1.75 g/kg(6) LD50 (rat, IP): 4 g/kg LD50 (rat, oral): 5.9 g/kg LD50 (rat, SC): 6.6 g/kg