Syrosingopine is an antihypertensive medication used to treat high blood pressure. It belongs to a class of drugs known as calcium channel blockers, which work by relaxing the blood vessels, allowing blood to flow more easily and reducing strain on the heart. Syrosingopine is usually used in combination with other medications to lower blood pressure, and is typically taken once or twice a day. Common side effects include dizziness, headache, nausea, and fatigue.
Syrosingopine is a drug derived from reserpine, a naturally occurring alkaloid found in the Rauwolfia serpentina plant [Wikipedia]. It has two main applications:
- Treatment of hypertension: Syrosingopine was historically used to treat high blood pressure. It works by depleting peripheral stores of norepinephrine, a neurotransmitter that helps regulate blood pressure [Wikipedia]. However, it has largely been replaced by other medications due to its side effects.
- Potential cancer treatment: Recent research suggests that syrosingopine may be effective in treating cancer, particularly when combined with the diabetes drug metformin. The combination appears to target cancer cells' metabolism, making them more susceptible to cell death [Wikipedia]. Syrosingopine inhibits the transport of lactate, a byproduct of cellular respiration, out of cancer cells. This disrupts their energy metabolism and makes them more reliant on metformin to kill them [NCBI].
It is important to note that syrosingopine is still under investigation for cancer treatment and is not currently an approved use. More research is needed to determine its safety and efficacy.
Here are some additional points about syrosingopine:
- It is an orally active medication.
- It is available in some countries under the trade name Singoserp [Wikipedia].
- It can cause side effects such as dizziness, drowsiness, and headache [Wikipedia].