Solriamfetol

Solriamfetol (brand name Sunosi) is a medication used to improve wakefulness in adults with narcolepsy or obstructive sleep apnea (OSA). It is a norepinephrine-dopamine reuptake inhibitor (NDRI) that helps to increase alertness, reduce daytime sleepiness, and improve concentration. Solriamfetol is taken orally once daily, usually in the morning. Common side effects include headache, nausea, insomnia, and dry mouth.

Solriamfetol, sold under the brand name Sunosi, is a medication used to improve wakefulness in adults with excessive daytime sleepiness (EDS) associated with two specific sleep disorders:

• Narcolepsy: This is a chronic neurological condition characterized by excessive daytime sleepiness, cataplexy (sudden attacks of muscle weakness triggered by emotions), and sleep paralysis [1].
• Obstructive sleep apnea (OSA): This sleep disorder is caused by repeated episodes of upper airway blockage during sleep, leading to fragmented sleep and daytime sleepiness [2].

Here's a closer look at Solriamfetol's key features:

Function:

• Solriamfetol belongs to a class of medications called dopamine and norepinephrine reuptake inhibitors (NDRIs) [1]. It works by increasing the levels of these two neurotransmitters in the brain.
• Dopamine and norepinephrine play a crucial role in regulating wakefulness, alertness, and focus [3]. By boosting these neurotransmitters, Solriamfetol helps promote wakefulness and reduce sleepiness.

How it Differs from Other Wakefulness Promoters:

• Compared to some other medications used for EDS, such as modafinil or armodafinil, Solriamfetol appears to be more effective, particularly for treating EDS associated with OSA [4].

Administration and Onset of Action:

• Solriamfetol comes as a tablet taken orally, typically once a day in the morning with or without food [5].
• The exact onset of action can vary, but it generally takes 1-2 hours for Solriamfetol to start working, with peak effects occurring within 2-4 hours [5].