Prucalopride is a prescription medication used to treat chronic constipation in adults. It is an orally administered selective serotonin-4 (5-HT4) receptor agonist that is believed to work by stimulating the movement of the intestines, allowing for easier passage of stool. Common side effects include nausea, abdominal pain, diarrhea, and headache.
Prucalopride is a medication used to treat chronic constipation in adults [1, 2, 3]. Here's a closer look at its key features:
Type: Serotonin (5-HT4) receptor agonist
Main Use: Treating chronic idiopathic constipation (CIC) in adults. CIC is defined as difficult or infrequent bowel movements (occurring less than three times a week) that lasts for at least three months and isn't caused by an underlying medical condition or medication [2].
How it Works: Prucalopride works by stimulating the 5-HT4 receptors in the gut. This stimulation increases the movement of waste through the intestines, ultimately leading to a bowel movement [1].
Advantages over some laxatives:
- May be more effective for chronic constipation than some stimulant laxatives [4].
- Less likely to cause tolerance with long-term use compared to stimulant laxatives [5].
Things to Consider:
- Prucalopride is typically available as a tablet taken by mouth, once daily.
- It may take a few days to feel the full effects of the medication [3].
- Side effects can occur, including headache, abdominal pain, diarrhea, and nausea [2].
- There can be interactions with other medications, so it's important to tell your doctor about all medications you're taking [2].