Pleconaril is an antiviral medication used to treat respiratory tract infections caused by certain types of virus. It works by blocking the actions of viral proteins that are needed for viral replication. Pleconaril is usually taken in pill form, but it can also be given by injection. Common side effects include nausea, diarrhea, fatigue, and headache. Serious side effects are rare, but can include allergic reactions and liver problems.
Pleconaril is an investigational antiviral drug that was being developed by Schering-Plough for the prevention of asthma exacerbations and common cold symptoms in patients exposed to picornavirus respiratory infections. It works by inhibiting the replication of viruses in the Picornaviridae family, including rhinoviruses (the most common cause of the common cold) and enteroviruses.
Here's some additional information about Pleconaril:
- Mechanism of action: Pleconaril binds to a specific pocket in a protein on the surface of the virus. This binding prevents the virus from uncoating its RNA, which is essential for replication.
- Route of administration: Pleconaril can be administered orally or intranasally.
- Clinical trials: Pleconaril has been evaluated in a number of clinical trials, but it has not yet been approved by the U.S. Food and Drug Administration (FDA) or the European Medicines Agency (EMA). The development of Pleconaril was discontinued due to concerns about drug interactions.
It is important to note that Pleconaril is not a cure for the common cold or other picornavirus infections. It may only reduce the severity and duration of symptoms. If you are considering taking Pleconaril, it is important to talk to your doctor about the risks and benefits.