Pitofenone is an opioid analgesic medication used to treat moderate to severe pain. It is sold under the brand name Notussin and is a combination of codeine and phenylephrine. Codeine is an opiate agonist and works by binding to opioid receptors in the brain and central nervous system, blocking pain signals from being sent to the brain. Phenylephrine is a decongestant that works by narrowing blood vessels in the nose and throat to reduce swelling and congestion. It is available in liquid, tablet, and rectal suppository forms. Pitofenone is generally used for short-term pain relief and should not be used for more than five days.
Pitofenone is a medication used in Eastern Europe and India for the treatment of pain caused by smooth muscle spasms [1]. These spasms can occur in the digestive system, urinary tract, and uterus [1]. Pitofenone is typically used in combination with other medications, such as fenpiverinium bromide and metamizole sodium, to provide a more well-rounded pain-relieving effect [1].
Here's a breakdown of how Pitofenone works:
- Antispasmodic: Pitofenone works by relaxing smooth muscles, which can help to relieve pain caused by spasms [1].
Important things to know about Pitofenone:
- Availability: Pitofenone is not available in the United States or Western Europe [1].
- Brand Names: Pitofenone is sold under various brand names in Eastern Europe and India, including Spasmalgon, Revalgin, Spasgan, and Bral [1].
- Side Effects: Common side effects of Pitofenone include dry mouth, constipation, difficulty in urination, and heartburn [1]. More serious side effects can occur, so it is important to talk to your doctor about the risks and benefits of taking Pitofenone.