Functional Category
Antimicrobial preservative; chelating agent; sequestering agent; stabilizing agent.
Applications in Pharmaceutical Formulation
Pentetic acid is mainly used as a chelating agent in the preparation of imaging and contrast agents for radionuclide and magnetic resonance imaging.(1,2) It is also used as a carrier excipient for neutron-capture isotopes in, for example, radiotherapy.(3) Pentetic acid–isotope complexes have also been considered as model active substances in scintigraphic imaging studies.(4) Pentetic acid has been used to chelate metal ions to reduce formation of reactive oxygen species during lyophilization.(5)
Description
Pentetic acid occurs as a white crystalline solid and is almost odorless.
Stability and Storage Conditions
Pentetic acid should be stored in well-closed containers in a cool, dry place.
Incompatibilities
The activity of pentetic acid as a chelating agent may cause unwanted effects in formulations containing metal ions. The desired chelate may be displaced by other ions from the formulation.
Safety
Pentetic acid is used in intrathecal and intravenous injection preparations. The pure form of pentetic acid is moderately toxic by the intraperitoneal route. LD50 (mouse, IP): 0.54 g/kg(9) LD50 (mouse, oral): 4.84 g/kg(10)