Osaterone is a synthetic anabolic androgenic steroid (AAS) derived from testosterone. It is used to treat male hypogonadism, delayed puberty in males, and in some cases breast cancer in women. It is used off-label for a variety of other indications, including bodybuilding, weight gain, and increasing muscle strength. Osaterone is available in capsules, tablets, and injectable forms. Side effects of the drug may include acne, virilization, and liver toxicity. Osaterone also known as 17α-hydroxy-6-chloro-2-oxa-6-dehydroprogesterone, as well as 2-oxachloromadinone, is a steroidal antiandrogen and progestin that was never marketed. The C17α acetate ester of osaterone, osaterone acetate, in contrast, has been marketed.
Osaterone, also sold under the brand name Ypozane, is a medication specifically used in veterinary medicine for dogs [1]. Here's a breakdown of its key features:
Function:
- Osaterone acts as an antiandrogen, meaning it counteracts the effects of male sex hormones like testosterone [1, 2]. It does this in two ways:
- Blocking the transport of testosterone into the prostate gland.
- Reducing the production of receptors for testosterone within the prostate.
Use in Dogs:
- Osaterone is primarily used to treat benign prostatic hyperplasia (BPH) in male dogs [1, 3]. BPH is a non-cancerous enlargement of the prostate gland, which can cause various urinary problems.
How it Works:
- By reducing the influence of testosterone on the prostate, Osaterone helps shrink the enlarged gland and alleviate symptoms associated with BPH, such as difficulty urinating, straining to urinate, and bloody urine [3].
Administration:
- Osaterone is typically given to dogs orally in tablet form [1]. The dosage and treatment duration will depend on the severity of the BPH and your veterinarian's recommendations.
Considerations:
- Osaterone is generally well-tolerated in dogs, but some potential side effects include lethargy, decreased appetite, and vomiting [1].
- It may interact with other medications your dog is taking, so inform your veterinarian about any existing medications.
- Osaterone is not suitable for all dogs, particularly those with certain medical conditions or pregnant/lactating females [1].
Important Note:
- Osaterone is a prescription medication and should only be used under the supervision of a veterinarian. They will determine if Osaterone is the right treatment for your dog's BPH and monitor for any potential side effects.