Ornithine oxoglutarate (also known as ornithine alpha-ketoglutarate or OAKG) is a dietary supplement that is often used to support athletic performance, increase muscle growth, and improve liver health. It is a combination of two amino acids: ornithine and alpha-ketoglutarate (AKG). Ornithine is an amino acid that helps the body break down proteins and is important for the synthesis of arginine and citrulline. AKG is an important component of the Krebs cycle and is involved in providing energy for the body. OAKG is thought to provide a number of benefits, including improved strength, endurance, and recovery from exercise as well as a decrease in fatigue and improved liver health.
Ornithine oxoglutarate (OGO), also sometimes called ornithine alpha-ketoglutarate (OKG), is a compound with potential health benefits, particularly related to the liver [1, 2]. Here's a closer look:
Components:
- OGO is a combination of two molecules:
- Ornithine: An amino acid involved in the urea cycle for waste removal and creatine synthesis for muscle energy [3, 4].
- Alpha-ketoglutarate (AKG): A molecule involved in various cellular processes, including energy production and protein synthesis [5].
Medical Uses:
- Liver disease: OGO is primarily used in some parts of the world to support liver function, particularly in cases of liver cirrhosis or hepatic encephalopathy (confusion due to liver problems) [1, 6]. It's thought to work by promoting ammonia removal through the urea cycle and potentially aiding energy production in liver cells.
- Important note: The evidence for OGO's effectiveness in liver disease is mixed, and more research is needed. It should not be used as a replacement for standard medical treatment for liver problems [6].
Other Potential Uses:
- There's limited research on OGO's benefits for other conditions, such as wound healing or improving recovery after surgery [7, 8].
Considerations:
- OGO is generally well-tolerated, but potential side effects include nausea, vomiting, and diarrhea [2].
- It may interact with certain medications, so inform your doctor about any medications you're taking before using OGO [2].
- Pregnant or breastfeeding women and people with certain medical conditions should consult a doctor before taking OGO due to potential risks [2].