Netupitant

Netupitant is a medication used to help prevent nausea and vomiting caused by chemotherapy [1, 2]. Here's a breakdown of its key features:

• Function: Netupitant works by blocking a substance called substance P (neurokinin 1) in the body. Substance P plays a role in nausea and vomiting signals sent by the brain [1]. By blocking this pathway, netupitant helps prevent these signals from reaching the vomiting center in the brain, thereby reducing nausea and vomiting.
• Use case: Netupitant is typically used in combination with other medications, like granisetron and palonosetron, for the prevention of acute and delayed nausea and vomiting (CINV) induced by chemotherapy [1, 2].
  • Acute CINV: Occurs within the first 24 hours after chemotherapy.
  • Delayed CINV: Occurs 1-5 days after chemotherapy.
• Dosage form: Netupitant comes as a tablet taken orally, usually along with other anti-emetic medications before starting chemotherapy [1].

Important considerations for Netupitant:

• Not for all chemotherapy: Netupitant may not be effective in preventing nausea and vomiting caused by all types of chemotherapy [2]. Your doctor will determine if it's suitable for your specific chemotherapy regimen.
• Side effects: Netupitant can cause side effects like headache, constipation, fatigue, and dizziness [1].
• Drug interactions: Netupitant can interact with other medications. Inform your doctor about all medications, supplements, or herbal remedies you take before starting netupitant.
• Not a first-line treatment: Netupitant is usually used for patients who are considered to be at high risk of developing CINV based on the type and dose of chemotherapy they are receiving [2].