Naldemedine

Naldemedine is an opioid-receptor antagonist medication used to treat opioid-induced constipation (OIC) in adults with chronic non-cancer pain. It is a peripherally-acting mu-opioid receptor antagonist (PAMORA) that works by blocking the effects of opioids on the gastrointestinal tract, thereby preventing opioid-induced constipation. Naldemedine is available as a tablet taken orally once daily with or without food. Common side effects include abdominal pain, nausea, and diarrhea.

Naldemedine is a medication used to specifically address constipation caused by opioid pain medications in adults with chronic, non-cancer pain [5]. Here's a breakdown of its key points:

• Function: Peripherally acting mu-opioid receptor antagonist [4]. This means it blocks the effects of opioid medication on the intestines, relieving constipation but with minimal effect on the pain relieving properties in the central nervous system [3].
• Brand Names: Symproic (US) and Rizmoic (EU) [3].
• Form: Taken as a tablet by mouth, typically once daily [5].

Important to Remember:

• Naldemedine is not prescribed for general constipation or constipation unrelated to opioid use [5].
• It's best to consult with a doctor to determine if Naldemedine is the right treatment for you. They can also advise on proper dosage and potential side effects [5].