Functional Category
Emollient; oleaginous vehicle; skin penetrant; solvent.
Applications in Pharmaceutical Formulation
Isopropyl palmitate is a nongreasy emollient with good spreading characteristics, used in topical pharmaceutical formulations and cosmetics such as: bath oils; creams; lotions; make-up; hair care products; deodorants; lip products; suntan preparations; and pressed powders; see Table I. Isopropyl palmitate is an established penetration enhancer for transdermal systems. It has also been used in controlled-release percutaneous films.
Description
Isopropyl palmitate is a clear, colorless to pale yellow-colored, practically odorless viscous liquid that solidifies at less than 168C.
Stability and Storage Conditions
Isopropyl palmitate is resistant to oxidation and hydrolysis, and does not become rancid. It should be stored in a well-closed container, above 168C, and protected from light.
Incompatibilities
See Isopropyl Myristate.
Safety
Isopropyl palmitate is widely used in cosmetics and topical pharmaceutical formulations, and is generally regarded as a relatively nontoxic and nonirritant material.(1–3) LD50 (mouse, IP): 0.1 g/kg(4)