Flumedroxone is a corticosteroid medicine used to treat a wide range of inflammatory and allergic conditions. It is used to reduce inflammation in conditions such as asthma, eczema, and rheumatoid arthritis. It may also be used to treat other conditions as determined by your doctor. Flumedroxone works by blocking certain substances in the body that cause inflammation.
Flumedroxone is a steroidal progestogen, a synthetic pregnane steroid, and a derivative of progesterone and 17α-hydroxyprogesterone . It was never marketed itself, but its derivative, flumedroxone acetate, was sold under the brand names Demigran and Leomigran as an antimigraine medication taken by mouth.
Flumedroxone acetate belongs to the class of medications known as progestins, which are synthetic versions of the female sex hormone progesterone. Exactly how it works to prevent migraines is not known.
Flumedroxone acetate was not widely prescribed due to concerns about its side effects, including blood clots and liver problems. It is no longer available in most countries.
Here's some additional information about flumedroxone acetate:
- Chemical Identifiers
- InChI: InChI=1S/C22H29F3O3/c1-12(26)21(28)9-6-16-14-11-18(22(23,24)25)17-10-13(27)4-7-19(17,2)15(14)5-8-20(16,21)3/h10,14-16,18,28H,4-9,11H2,1-3H3/t14-,15+,16+,18+,19-,20+,21+/m1/s1
- IUPAC Name: (1S,2R,8S,10R,11S,14R,15S)-14-acetyl-14-hydroxy-2,15-dimethyl-8-(trifluoromethyl)tetracyclo[8.7.0.02,7.011,15]heptadec-6-en-5-one
- Other names
- 17α-Hydroxy-6α-(trifluoromethyl)pregn-4-ene-3,20-dione
- 6α-Trifluoromethyl-17α-hydroxyprogesterone