Ecallantide (brand name Kalbitor) is a prescription medicine used to treat acute attacks of hereditary angioedema (HAE) in people 16 years of age and older. HAE is a rare, inherited condition that causes episodes of swelling in different parts of the body, including the throat, hands, feet, face, and abdomen. Ecallantide works by blocking the action of certain proteins in the body that cause swelling during an HAE attack. It is administered as an injection into the muscle or under the skin.
Ecallantide is a medication used to treat attacks of hereditary angioedema (HAE) . It is a rare genetic disorder that causes swelling of the skin, mucous membranes, abdomen, and airways. Ecallantide is also being studied to prevent blood loss in certain surgeries.
Ecallantide works by blocking a protein called kallikrein, which is involved in the body's inflammatory response. By blocking kallikrein, ecallantide can help to reduce swelling and pain caused by HAE attacks.
Ecallantide is given as an injection under the skin (subcutaneously). The usual dose is 30 milligrams (mg), which may be given in two divided doses of 15 mg each. An additional 30 mg dose may be given if needed within 24 hours.
Ecallantide is generally well-tolerated, but some people may experience side effects such as injection site reactions (pain, redness, swelling, itching), nausea, vomiting, headache, dizziness, or fatigue. There is also a small risk of serious allergic reactions (anaphylaxis).
Ecallantide is a prescription medication and should only be used under the supervision of a doctor. Ecallantide is not a cure for HAE, but it can help to control symptoms and improve quality of life for people with this condition.