Functional Category
Adsorbent
Applications in Pharmaceutical Formulation
Attapulgite is widely used as an adsorbent in solid dosage forms. Colloidal clays (such as attapulgite) absorb considerable amounts of water to form gels and in concentrations of 2–5% w/v usually form oil-in-water emulsions. Activated attapulgite, which is attapulgite that has been carefully heated to increase its absorptive capacity, is used therapeutically as an adjunct in the management of diarrhea.
Description
Attapulgite occurs as a light cream colored, very fine powder. Particle size ranges depend on the grade and manufacturer.
Stability and Storage Conditions
Attapulgite can adsorb water. It should be stored in an airtight container in a cool, dry, location
Incompatibilities
Attapulgite may decrease the bioavailability of some drugs such as loperamide(2) and riboflavin.(3) Oxidation of hydrocortisone is increased in the presence of attapulgite.
Safety
Attapulgite is widely used in pharmaceutical formulations and is generally regarded as an essentially nontoxic and nonirritant material. It is not absorbed following oral administration. In oral preparations, activated attapulgite up to 9 g is used in daily divided doses as an adjunct in the management of diarrhea.(5) LD50 (rat, IP): 0.34 g/kg